Katja Zirlik Selected Research

Syk Kinase

1/2016	From CLL to Multiple Myeloma - Spleen Tyrosine Kinase (SYK) influences multiple myeloma cell survival and migration.
1/2016	Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia.
2/2014	Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk.
9/2011	The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice.
6/2010	Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia.
7/2009	Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

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Katja Zirlik Research Topics

Disease

12	Neoplasms (Cancer) 01/2018 - 04/2006
10	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2018 - 07/2009
4	B-Cell Lymphoma (Lymphoma, B Cell) 05/2015 - 04/2006
4	Atherosclerosis 09/2011 - 04/2010
3	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 01/2018 - 09/2010
2	Leukemia 01/2018 - 08/2014
2	Trisomy (Trisomies) 01/2018 - 01/2012
2	Adenocarcinoma 12/2016 - 03/2014
2	Multiple Myeloma 01/2016 - 08/2007
2	Inflammation (Inflammations) 09/2011 - 04/2010
2	Lymphoma (Lymphomas) 08/2007 - 11/2006
1	Hematologic Neoplasms (Hematological Malignancy) 01/2018
1	Melanoma (Melanoma, Malignant) 11/2014
1	Multiple Sclerosis 08/2014
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2014
1	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 02/2014
1	Esophageal Neoplasms (Esophageal Cancer) 07/2013
1	Rheumatoid Arthritis 09/2011
1	Asthma (Bronchial Asthma) 09/2011
1	Atherosclerotic Plaque (Atheroma) 07/2010
1	Coronary Disease (Coronary Heart Disease) 07/2010
1	Acute Coronary Syndrome 05/2010
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 05/2010
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2010
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2010
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2008
1	Plasmacytoma 08/2007
1	Hepatitis B 04/2006

Drug/Important Bio-Agent (IBA)

6	Syk KinaseIBA 01/2016 - 07/2009
3	Phosphotransferases (Kinase)IBA 01/2018 - 02/2014
2	Pharmaceutical PreparationsIBA 01/2018 - 09/2008
2	Biological ProductsIBA 01/2018 - 12/2011
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2012
2	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 05/2015 - 09/2012
2	EpitopesIBA 09/2012 - 09/2010
2	AntigensIBA 09/2012 - 11/2006
2	LigandsIBA 01/2012 - 08/2007
2	LDL Receptors (LDL Receptor)IBA 09/2011 - 07/2010
2	Immunoglobulin Idiotypes (Idiotype, Immunoglobulin)IBA 09/2010 - 11/2006
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 07/2010 - 05/2010
2	Immunoglobulins (Immunoglobulin)IBA 11/2006 - 04/2006
2	VaccinesIBA 11/2006 - 04/2006
1	idelalisibIBA 01/2018
1	Oxygen (Dioxygen)IBA 01/2018
1	ibrutinibIBA 01/2018
1	Rituximab (Mabthera)FDA Link 01/2018
1	Bendamustine Hydrochloride FDA Link 01/2018
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2018
1	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 01/2018
1	Epirubicin (Ellence)FDA LinkGeneric 12/2016
1	Docetaxel (Taxotere)FDA Link 12/2016
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2016
1	Fluorouracil (Carac)FDA LinkGeneric 12/2016
1	Leucovorin (Folinic Acid)FDA Link 12/2016
1	Cisplatin (Platino)FDA LinkGeneric 12/2016
1	Capecitabine (Xeloda)FDA Link 12/2016
1	AutoantigensIBA 05/2015
1	Polysaccharides (Glycans)IBA 05/2015
1	LectinsIBA 05/2015
1	VemurafenibIBA 11/2014
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2014
1	tyrosine receptor (receptor, tyrosine)IBA 11/2014
1	A-factor (Streptomyces)IBA 08/2014
1	Sphingosine-1-Phosphate ReceptorsIBA 08/2014
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 08/2014
1	GTP-Binding Proteins (G-Protein)IBA 08/2014
1	CXCR4 Receptors (CXCR4 Receptor)IBA 05/2014
1	proto-oncogene proteins pimIBA 05/2014
1	Insulin (Novolin)FDA Link 08/2013
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2013
1	Complementarity Determining Regions (Complementarity Determining Region)IBA 09/2012
1	fostamatinibIBA 09/2011
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 11/2010
1	CholesterolIBA 07/2010
1	RNA (Ribonucleic Acid)IBA 07/2010
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 07/2010
1	IntegrinsIBA 06/2010
1	Cytotoxins (Cytolysins)IBA 06/2010
1	ChemokinesIBA 06/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2010
1	TNF Receptor-Associated Factor 1IBA 05/2010
1	Messenger RNA (mRNA)IBA 05/2010
1	Vorinostat FDA Link 05/2010
1	Interleukin-6 (Interleukin 6)IBA 04/2010
1	CD40 Ligand (CD40L)IBA 04/2010
1	CytokinesIBA 04/2010
1	Imatinib Mesylate (Gleevec)FDA Link 09/2008
1	LipidsIBA 04/2006
1	Immunoglobulin Fab FragmentsIBA 04/2006
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2006
1	Neoplasm Antigens (Tumor Antigens)IBA 04/2006

Therapy/Procedure

4	Therapeutics 01/2018 - 08/2007
3	Drug Therapy (Chemotherapy) 01/2018 - 03/2014
2	Neoadjuvant Therapy 03/2014 - 07/2013
2	Esophagectomy 03/2014 - 07/2013
1	Intravenous Infusions 12/2016
1	Combined Modality Therapy 03/2014
1	Transplantation 05/2010